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Description
Ku80 Monoclonal Antibody (MEM-54). The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Immunogen
n/a
Other Names
FLJ39089, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, DNA repair protein XRCC5, Ku autoantigen, 80kDa, Ku86 autoantigen related protein 1, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining, Ku autoantigen, 80kD), X-ray repair cross-complementing protein 5, X-ray repair, complem