Immunohistochemistry: 5 μg/mL, peptide-ELISA: 1:16000, Western Blot: 0.1-0.3 μg/mL
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Description
Ku80 Polyclonal Antibody. The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of VJ recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo VJ recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Immunogen
n/a
Other Names
XRCC5; KU80; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining Ku autoantigen, 80kDa) ; HGNC:12833; KARP-1; KARP1; Ku86; NFIV ; ATP-dependent DNA helicase II; DNA repair protein XRCC5; Ku86 autoantigen related protein 1; Ku autoantigen, 80kD; X-ray repair, complementing defective, repair in Chinese hamster