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Description
Ku80 Polyclonal Antibody. X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is a single stranded DNA-dependent ATP-dependent helicase. It is involved in chromosome translocation. Ku80 along with Ku70 forms a heterodimeric protein originally identified as autoantigens, associated with several autoimmune diseases including scleroderma, polymyositis and systemic lupus erythematosus. Ku is a widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells.
Immunogen
n/a
Other Names
KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, DNA repair protein XRCC5, Ku autoantigen, 80kDa, Ku86 autoantigen related protein 1, TLAA, X-ray