human, mouse, rat, bovine, canine, chicken/avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep, simian, other
Isotype
n/a
Format
immunoaffinity purified
Size
600 μg
Concentration
3 mg/ml
Applications
WB, IF
Reviews / Ratings
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Description
Goat polyclonal antibody to Catenin (cadherin-associated protein), beta 1. Beta Catenin is a 88 kDa protein and is a key downstream effector in the Wnt signalling pathway. It is involved in early embryonic development and tumorigenesis. Beta Catenin is part of a complex of proteins that constitute adherens junctions, necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. This protein anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Detects a band of approximately 95 kDa by Western blot in MNT1 and SH-SY5Y cell lysates.
Immunogen
Purified recombinant peptide derived from within residues 731 aa to the C-terminus of human beta Catenin produced in E. coli.