Recombinant Influenza A virus Polymerase acidic protein (PA), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 18.6kDa. Partial: 124-247aa. N-terminal 6xHis-tagged. Influenza A virus (strain A/x-31 H3N2). Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.