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Description
Cyclin B2 Monoclonal Antibody (X29.2). Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). The protein encoded by the CCNB2 gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Cyclin B2 steadily accumulates during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B2 is required for cell cycle progression, as destruction resistant mutants cause mitotic arrest. Cyclins B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region.