Immunohistochemistry (Paraffin): 5-10 μg/mL, Western Blot: 0.25-1 μg/mL
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Description
eIF3a Polyclonal Antibody. eIF3A is an important protein involved in protein translation/synthesis. It is a 1382 amino acid member of the eIF-3 subunit A family with a PCI domain and a component of the eIF-3 multiprotein complex composed of at least 13 different subunits. It interacts with eIF3B and intermediate filament protein K7 (cytokeratin 7). A function of eIF3A is to bind to the 40S ribosome and promote the binding of methionyl-tRNAi and mRNA and thus stabilize the translation initiation complex. This protein synthesis factor may also act as an adapter molecule between the translation initiation apparatus and the cytoskeleton structure in the cell. eIF3A may be required for cell division and is also involved in breast, cervical, esop