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Description
RBCK1 Polyclonal Antibody. E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the L
Immunogen
n/a
Other Names
RanBP-type and C3HC4-type zinc finger-containing protein 1; Ubiquitin-conjugating enzyme 7-interacting protein 3; Hepatitis B virus X-associated protein 4; HBV-associated factor 4; RING finger protein 54;