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| Antigenic Specificity | BUBR1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 μg/mL, Immunofluorescence: 2 μg/mL, Western Blot: 1-2 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BUBR1 Polyclonal Antibody. BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has |
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| Immunogen | n/a |
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| Other Names | BUB1 Mitotic Checkpoint Serine/Threonine Kinase B |
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| Gene, Accession # | Entrez: 701; Uniprot: O60566 |
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| Catalog # | 720297 |
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| Price | |
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| Order / More Info | BUBR1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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