A diterpenoid with anti-inflammatory and anticancer properties; an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 μM, respectively); inhibits proliferation of KYSE70, KYSE410, and KYSE450 esophageal cancer cells, halts the cell cycle at the G2/M phase, and induces apoptosis at 20 μM; decreases the protein levels of phosphorylated AKT and reduces AKT activity; reduces tumor growth in patient-derived mouse tumor models at 40 and 160 mg/kg; an inhibitor of NLRP3 inflammasome assembly and activation; inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes at 3 mg/kg