Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2000
Reviews / Ratings
If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
SLC25A13 Polyclonal Antibody. Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD). CTLN2 is an autosomal recessive disease that
Immunogen
n/a
Other Names
ARALAR2; Calcium binding mitochondrial carrier protein Aralar2; Calcium-binding mitochondrial carrier protein Aralar2; Citrin; CMC2_HUMAN; CTLN2; Ctrn; Mitochondrial aspartate glutamate carrier 2; RGD1565889; Slc25a13; Solute carrier family 25 (citrin) member 13; Solute carrier family 25 member 13 (citrin); Solute carrier family 25 member 13;