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Description
PIK3AP1 Monoclonal Antibody (OTI7A11). Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Immunogen
n/a
Other Names
Pik3ap1, 1810044J04Rik, B cell adaptor protein, BCAPB-cell adapter for phosphoinositide 3-kinase, B-cell phosphoinositide 3-kinase adapter protein 1, FLJ35564, phosphoinositide 3-kinase adapter protein 1, phosphoinositide-3-kinase adaptor protein 1, RP11-34E5.3