Immunohistochemistry (Paraffin): 1:2000, Western Blot: 1:2000
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Description
LSM11 Monoclonal Antibody (OTI2G7). LSm11 is a 360 amino acid protein that localizes to the nucleus and belongs to the LSm subfamily of snRNP Sm proteins. Containing an N-terminal domain that is necessary for pre-mRNA cleavage, LSm11 functions to binds specifically to U7 snRNA and is thought to play a role in cell cycle regulation and cell growth. The gene encoding LSm11 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Immunogen
n/a
Other Names
2210404M20Rik, LSM11 homolog, U7 small nuclear RNA associated, U7 snRNA-associated Sm-like protein LSm11