Immunoprecipitation: 2-10 μg/mg lysate, Western Blot: 1:2,000-1:10,000
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Description
Dclre1c/Artemis Polyclonal Antibody. Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins.
Immunogen
n/a
Other Names
ASCID, DCLRE1C DNA cross link repair 1C, DCLRE1C protein, DCLREC1C, DNA cross link repair 1C, FLJ11360, RS SCID, SCIDA, Severe combined immunodeficien