Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000
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Description
NAB2 Monoclonal Antibody (OTI1E12). Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2
Immunogen
n/a
Other Names
MADER, EGR-1-binding protein 2, EGR1 binding protein 2, NGFI-A-binding protein 2, melanoma-associated delayed early response protein