bovine, canine, guinea pig, human, mouse, porcine, rabbit, rat
Isotype
n/a
Format
purified
Size
100 μl
Concentration
n/a
Applications
Western Blot: 0.2-1 μg/mL
Reviews / Ratings
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Description
GALE Polyclonal Antibody. This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symp