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| Antigenic Specificity | MKP2 |
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| Clone | AFPK7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | ELISA: Assay Dependent, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MKP2 Monoclonal Antibody (AFPK7). There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain. MKP2 is expressed in a variety of tissues, and is localized in the nucleus. Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation. MKP2 is a novel transcription target of p53 in mediating apoptosis by 10-bp palindrome motif (CTGGCGCCAG) in the MKP |
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| Immunogen | n/a |
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| Other Names | Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2; Dual specificity protein phosphatase hVH2; DUSP-4; DUSP 4; MKPII; MKP II |
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| Gene, Accession # | Entrez: 1846; Uniprot: Q13115 |
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| Catalog # | MA5-17225 |
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| Price | |
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| Order / More Info | MKP2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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