Immunocytochemistry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Western Blot: 1:1000
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Description
MKP3 Polyclonal Antibody. DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variet
Immunogen
n/a
Other Names
Dual specificity protein phosphatase 6; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3; Dual specificity protein phosphatase PYST1; MKP3