Immunohistochemistry: 2 μg/mL, Western Blot: 1 μg/mL
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Description
NADE Polyclonal Antibody. The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA ex
Immunogen
n/a
Other Names
RP13-349O20.1, BEX3, Bex, DXS6984E, HGR74, NADE; brain expressed, X-linked 3; brain-expressed X-linked protein 3; nerve growth factor receptor-associated protein 1; ovarian granulosa cell 13.0 kDa protein HGR74; ovarian granulosa cell protein (13kD); p75NTR-associated cell death executor; protein BEX3