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Description
Phospho-IR/IGF1R (Tyr1162, Tyr1163) Polyclonal Antibody. Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptors, both of which are receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The IR and IGF-1R are heterotetrameric proteins consisting of two ligand-binding alpha subunits, which are completely extracellular, and two beta subunits that span the membrane with an intracellular portion that each contain a tyrosine kinase domain. These disulfide-linked subunits are in a beta-alpha-alpha-beta configuration in the mature receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of the receptor an