Immunoprecipitation: Assay-Dependent, Western Blot: 1:500-1:3000
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Description
4-1BB Ligand Polyclonal Antibody. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required
Immunogen
n/a
Other Names
4-1BB-L, CD137L, 4-1BB ligand, 4-1BBL, homolog of mouse 4-1BB-L, receptor 4-1BB ligand, tumor necrosis factor ligand superfamily member 9