Immunocytochemistry: 1:50-1:5000, Immunofluorescence: 1:50-1:500, Immunohistochemistry (Paraffin): 1:100-1:500, Western Blot: 1:500-1:5000
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Description
Chromogranin A Monoclonal Antibody (SP12). Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
Immunogen
n/a
Other Names
SP-I, betagranin (N-terminal fragment of chromogranin A), chromogranin-A, parathyroid secretory protein 1, pituitary secretory protein I