A potent inhibitor of MELK (IC50 = 0.41 nM); blocks the phosphorylation of MELK-specific substrates and reduces the ability of MCF-7 breast cancer cells to invade and form spheroids in Matrigel; suppresses the growth of xenograft tumors in mice
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
1431697-89-0 MELK maternal embryonic leucine zipper kinase inhibitor inhibit biochemical OTSSP 167 protein kinases cancer intracellular signaling stem cell research apoptosis breast cancer phosphorylation MCF-7 MCF7 matrigel xenograft tumor