An anti-malarial compound; active against P. falciparum in vitro (IC50 = 1.28 nM); an iron(II) oxide-reactive endoperoxide that generates ROS; inhibits proliferation of germinal center B cells in vitro; prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis; inhibits bleomycin-induced alveolitis and pulmonary fibrosis in rats ,