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Description
EXT2 Polyclonal Antibody. Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the formation of exostoses (EXT), which are cartilage-capped bony protuberances mainly located on long bones . Two proteins associated with EXT, EXT1 and EXT2, form homo/heteromeric complexes in vivo, which leads to the accumulation of both proteins in the Golgi apparatus . EXT1 and EXT2 are endoplasmic reticulum-localized type II transmembrane glycoproteins that possess, or are tightly associated with, glycosyltransferase activities involved in the polymerization of the glycosaminoglycan, heparan sulfate (HS). EXT2 is a protein that harbors the D-glucuronyl (GlcA) and N-acetyl-D-glucosaminyl (GlcNAc) transferase activities requi
Immunogen
n/a
Other Names
Exostosin-2; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N; acetylglucosaminyl-proteoglycan 4-alpha-N; acetylglucosaminyltransferase; Multiple exostoses protein 2; Putative tumor suppressor protein EXT2; EXT2