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Description
Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.Subcellular location: Membrane, Single-pass type I membrane proteinTissue specificity: Central nervous system, skeletal muscle and aorta tissues.Miscellaneous: Binds gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, CACNL2A, CCHL2A, MHS3.
Immunogen
A synthetic peptide from aa region 100-150 of human CACNA2D1 conjugated to an immunogenic carrier protein was used as the antigen.