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| Antigenic Specificity | Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (Internal Region) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity.Tissue specificity: Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophiles of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level).Subcellular location: Membrane, Single-pass type I membrane proteinMiscellaneous: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-4, Voltage-gated calcium channel subunit alpha-2/delta-4. |
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| Immunogen | A synthetic peptide from the internal region of human CACNA2D4 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 95% identity with mouse sequence. |
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| Other Names | cacna2d4|cacna2d3b|si:ch211-87p6.2|RCD4|5730412N02Rik|BE686333|RGD1562038 |
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| Gene, Accession # | Gene ID: 93589 |
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| Catalog # | ABIN350154 |
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| Price | |
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| Order / More Info | Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (Internal Region) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 12181424, 17033974 |
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