If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Anti-TNFRSF8 (Brentuximab-HC-K121)-DBCO-MMAF ADC. This Antibody-Drug Conjugate (ADC) product is comprised of an anti-TNFRSF8 monoclonal antibody (Brentuximab variant,HC-K121) conjugated via a DBCO linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.