Purity ≥98% by SDS-PAGE gel and HPLC analyses. IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains.It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles.The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NF-kappaB in cells that express the IL-17BR receptor.Recombinant human IL-17E is a 33.8kD disulfide-linked homodimer of two 145 amino acid polypeptide chains. Biological Activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100ng. AA Sequence: MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT HKGYCLERRL YRVSLACVCV RPRVMG Quality Control: Verified by N-termin