Purity ~98% (SDS-PAGE, HPLC). IL-17E is a disulfide-linked homodimer of two 145aa polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NK-kB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8kD disulfide-linked homodimer of two 145aa polypeptide chains. Source: Recombinant protein corresponding to human IL-17E, expressed in E. coli. Molecular Weight: ~33.8kD Endotoxin: <0.1ng/ug