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Description
Rabbit Anti-Human DFFA polyclonal antibody for IHC-P. Apoptosis is induced through a number of cell death receptors and their ligands like TNF and TNF receptor. The signaling cascade is carried further by adaptor proteins containing death domains and by caspase family of proteins. DFF-45 and DFF-40 (ICAD and CAD) are two subunits of heterodimeric caspase activated DNAse. DFF-45/ICAD (Inhibitor of Caspase Activated DNAse) acts as a chaperon for appropriate folding of DFF-40 and it also acts as inhibitor of DFF-40. Caspase 3 upon activation cleaves DFF to release DFF-40/CAD, which oligomerizes into a large active complex and eventually causes the degradation of DNA in nuclei. Hence cleavage of DFF-45 is an important step in apoptosis.