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Description
Mouse Anti-PAPPA Recombinant Antibody (1-1). Provided herein is a Mouse monoclonal antibody against Human Pappalysin 1. The antibody can be used for immunoassay techniques, such as WB, ELISA, IHC, IHC-P. PAPPA is a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers.
Immunogen
Purified human PAPP-A adsorbed onto aluminum hydroxide gel
Other Names
Pappalysin 1; Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease; Pregnancy-Associated Plasma Protein A, Pappalysin 1; Differentially Placenta 1 Expressed Protein; Aspecific BCL2 ARE-Binding Protein 2; IGF-Dependent IGFBP-4 Protease; IGFBP-4ase; PAPP-A; Insulin-Like Growth Factor-Dependent IGF-Binding Protein 4 Protease;