A CB1 antagonist and CB2 inverse agonist; Kis = 7.5 and 2,290 nM for CB1 and CB2 from rat forebrain and mouse spleen, respectively; agonist at GPR55 (EC50 = 39 nM); potentiates GABAA currents (EC50 = 0.4 μM); prevents TGF-β1-induced EMT in HK-2 renal tubule epithelial cells independent of CB receptors or GPR55; halts the cell cycle and induces apoptosis in A375 human melanoma cells; reduces antidepressant-like behavior and decreases fasting-induced hyperphagia in mice