A potent, ATP-competitive inhibitor of JAK2 that less effectively inhibits JAK3 (IC50s = 3 and 48 nM, respectively); inhibits JAK2 containing the V617F mutation (IC50 = 20 nM); reduces the growth of Ba/F3 pro-B-cells in SCID mice without affecting erythroid progenitors, reticulocytes, or platelets
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
1229236-87-6 biochemical inhibitor kinase protein kinase cancer intracellular signaling signal transduction gandotinib LY 2784544 potent inhibit ATP-competitive janus kinase 2 JAK2 JAK JAK3 3 V617F mutation block STAT5 STAT 5 phosphorylation proliferation Ba/F3 pro-B-cells proB oral gavage reduce reduction growth SCID mice hematological malignancy malignancies