If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
PDGFRA(Tyr572)+PDGFRB(Tyr579) Antibody, Biotin Conjugated. ? Target Background: The PDGF Receptor Type A (Alpha platelet-derived growth factor receptor precursor, CD140a antigen), a 170kD protein, binds all three isoforms of PDGF with high affinity whereas the PDGF Receptor Type B, a 190kD protein, appears to bind only the PDGF BB homodimer with high affinity. Both receptors are transmembranous, ligand activated protein tyrosine kinases, which phosphorylate a number of important signal transduction proteins, which are bound with differential affinities via SH2 domains. The
Immunogen
KLH conjugated synthetic phosphopeptide derived from human PDGFRA around the phosphorylation site of Tyr572 [HE(p-Y)IY]