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Description
Anti-Smac/Diablo Antibody validated for WB in Human. No cross reactivity with other proteins. Diablo homolog??(DIABLO), also referred to as??second mitochondria-derived activator of caspases??or??SMAC, is a??mitochondrial??protein??that in humans is encoded by the??DIABLO??(direct??IAP??binding protein with low pI)??gene??on chromosome 12. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. ??A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen
n/a
Other Names
Diablo homolog, mitochondrial;Direct IAP-binding protein with low pI;Second mitochondria-derived activator of caspase;Smac;Diablo;Smac;