Solute Carrier Family 47, Member 1 (SLC47A1) (aa 500-550)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
Function: Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium), a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.Subcellular location: Cell membrane, Multi-pass membrane protein. Note: Predominantly localized at the plasma membrane but also found in intracellular organelles.Tissue specificity: Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes). Also known as: MATE-1, Solute carrier family 47 member 1, SLC47A1.
Immunogen
A synthetic peptide from aa region 500-550 of human SLC47A1 (MATE1) conjugated to an immunogenic carrier protein was used as the antigen.