A quinazolinone alkaloid with diverse biological activities; inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 μM, respectively); selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 μM, for COX-1 and COX-2, respectively); slows cancer cell growth in vitro (GI50s = 8.41-31.6 μM); induces vasodilation (0.1-10 μM) in isolated rat aorta; decreases plasma levels of caffeine in rat through CYP1A2 and CYP2E1 metabolism induction at a dose of 80 mg/kg