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Description
Mouse Anti-TRDN Recombinant Antibody (IIG12). Provided herein is a Mouse monoclonal antibody, which binds to TRDN (Triadin). The antibody can be used for immunoassay techniques, such as BL, ICC, IF, IHC, IP, WB. TRDN contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction (PubMed:19398037, PubMed:17846166 and PubMed:7721813). TRDN is required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. It is required for normal skeletal muscle strength. TRDN plays a role in excitation-contraction coupling in the heart and in regulating th