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Description
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.Subcellular location: Cell membrane, Multi-pass membrane protein. Cell junction ?? synapse ?? postsynaptic cell membrane, Multi-pass membrane protein. Also known as: GRIA3, Glutamate receptor 3, GluR-3, GluR-c, GluR-K3, Glutamate receptor ionotropic, AMPA 3, AMPA-selective glutamate receptor 3, GLUR3.
Immunogen
A synthetic peptide from the c-terminal region of mouse Glutamate receptor 3 (AMPA 3) conjugated to an immunogenic carrier protein was used as the antigen.