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Description
Rabbit IgG polyclonal Picoband? antibody for Histone acetyltransferase KAT2A(KAT2A) detection. Tested with WB in Human. No cross reactivity with other proteins. Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene. It is mapped to 17q21. KAT2A, or GCN5, GCN5L2, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. The GCN5 protein, a regulator of transcription activation in yeast, promotes maximal levels of transcription by 2 transcriptional activators, GCN4 and the HAP2-HAP3-HAP4 complex. The GCN4 protein activates transcription of a large number of amino acid biosynthetic genes under limiting amino acid conditions and the HAP2-HAP3-HAP4 complex is thought to mediate transcription of genes involved in respiratory functions. GCN5 also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human KAT2A/GCN5 (75-106aa DPARPGLSQQQRASQRKAQVRGLPRAKKLEKL), identical to the related mouse and rat sequences.
Other Names
Histone acetyltransferase KAT2A;2.3.1.48;General control of amino acid synthesis protein 5-like 2;Histone acetyltransferase GCN5;HsGCN5;Lysine acetyltransferase 2A;STAF97;KAT2A;GCN5, GCN5L2, HGCN5;