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Description
BAIAP2, a target of p53, has been identified as a brain-specific angiogenesis inhibitor (BAI1) binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This BAIAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-518 amino acids from the C-terminal region of human BAIAP2.
Immunogen
Human BAIAP2.
Other Names
BAIAP2; Brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; BAP2; FLAF3; IRSP53; BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; IRS-58; IRSp53/58; Insulin receptor substrate p53