Immunofluorescence: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent
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Description
alpha Synuclein Monoclonal Antibody (n847). Alpha-Synuclein belongs to the Synuclein family, which includes beta and gamma Synuclein, and is predominantly expressed in neurons, and concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. Alpha-Synuclein is involved in the formation of SNARE complexes, and most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur
Immunogen
n/a
Other Names
NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, SYN, SYUA, alpha-synuclein, synuclein, alpha