LEGEND MAX? Mouse CCL8 (MCP-2) ELISA Kit with Pre-coated Plate
Description
CCL8, also known as MCP-2, is a CC chemokine of the monocyte chemoattractant protein (MCP) family that plays key roles in allergic and inflammatory responses. CCL8 (MCP-2) has structural and functional similarity to other family members MCP-1 and MCP-3, and is often co-expressed with these chemokines in mononuclear cells. CCL8 is also constitutively expressed in the skin and lymph nodes of mice. Mouse CCL8 induces a chemotactic migration of a population of differentiated Th2 cells enriched in IL-5 and IL-25 receptors by binding to the CCR8 receptor. Recent studies have established CCL8 as a critical ligand for driving CCR8-dependent Th2 cell trafficking into the skin, which in conjunction with locally recruited eosinophils drives chronic cutaneous allergic inflammation. CCL8 expression by suprabasal buldge cells has also been experimentally shown to negatively regulate the population of mouse hair follicles Langerhans cells, further underscoring this chemokines central contributions to maintaining cutaneous immunity. The BioLegend LEGEND MAX? Mouse CCL8 (MCP-2) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a rat monoclonal anti-mouse CCL8 (MCP-2) antibody. The detection antibody is a biotinylated goat polyclonal anti-mouse MCP-1 antibody. This kit is specifically designed for the accurate quantitation of mouse CCL8 (MCP-2) from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated with ready-to-use reagents.
Size
1 pre-coated plate
Concentration
n/a
Applications
ELISA
Other Names
Monocyte chemotactic protein 2 (MCP-2), small inducible cytokine subfamily A, member 8 (SCYA8),Chemokine (C-C motif) ligand 8, CCL8, MCP2, MCP-2