| Edit |   |
|---|
| Antigenic Specificity | Lck Interacting Transmembrane Adaptor 1 (LIME1) (aa 281-296) |
|---|
| Clone | LIME-10 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2a |
|---|
| Format | Protein A purified |
|---|
| Size | 0.1 mg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals. |
|---|
| Immunogen | COOH-terminal peptide comprising residues 281-296 of the human LIME conjugated to keyhole limpet hemocyanin. |
|---|
| Other Names | LIME1|DKFZp459A158|LIME|LP8067|dJ583P15.4|2810038K19Rik|RGD1562795 |
|---|
| Gene, Accession # | Gene ID: 54923 |
|---|
| Catalog # | ABIN94426 |
|---|
| Price | |
|---|
| Order / More Info | Lck Interacting Transmembrane Adaptor 1 (LIME1) (aa 281-296) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 15582487, 15286727, 14610046, 16160011 |
|---|