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Description
Rabbit IgG polyclonal Picoband? antibody for Eukaryotic translation initiation factor 3 subunit E(EIF3E) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. Eukaryotic translation initiation factor 3 subunit E is a protein that in humans is encoded by the EIF3E gene. The human homolog of EIF3E is located on chromosome region 8q22-q23. It is composed of 13 exons that span 45 kb of genomic DNA. EIF3E is the component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis ts localization/assembly. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). And the eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Immunogen
E.coli-derived human EIF3e recombinant protein (Position: A160-Q241). Human EIF3e shares 100% amino acid (aa) sequence identity with both mouse and rat EIF3e.
Other Names
Eukaryotic translation initiation factor 3 subunit E ;eIF3e ;Eukaryotic translation initiation factor 3 subunit 6 ;Viral integration site protein INT-6 homolog;eIF-3 p48 ;EIF3E ;EIF3S6 , INT6 ;