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Description
PAIP2 acts as a repressor in the regulation of translation initiation of poly (A) containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly (A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly (A) RNP structure organization. This PAIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human PAIP2.
Immunogen
Human PAIP2.
Other Names
PAIP2; PAIP2A; Polyadenylate-binding protein-interacting protein 2; PABP-interacting protein 2; PAIP-2; Poly(A)-binding protein-interacting protein 2; HSPC218