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Description
Rabbit IgG polyclonal Picoband? antibody for Fibrinogen gamma chain(FGG) detection. Tested with WB, IHC-P in Human;Mouse;Rat. No cross reactivity with other proteins. Fibrinogen gamma chain, also known as FGG, is a human gene found on Chromosome 4. The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human FGG (133-163aa IRYLQEIYNSNNQKIVNLKEKVAQLEAQCQE), different from the related mouse sequence by two amino acids, and from the related rat sequence by five amino acids.