Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 11 (SLC6A11)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
rat
Isotype
n/a
Format
affinity purified
Size
100 μL
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (IHC)
Reviews / Ratings
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Description
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-3 has been found to be localized to astrocytes within the cerebral cortex indicating that this transporter mediates GABA uptake into glial cells (Minelli et al., 1996). Anti-GAT-3 Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-3 protein.