Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 (SLC6A1) (aa 473-487), (C-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse, rat
Isotype
n/a
Format
immunogen affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reviews / Ratings
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Description
SLC6A1(Solute Carrier family 6(Neurotransmitter transporter, Gaba), Member 1), also called GABATR or GABATHG, encodes a gamma-aminobutyric acid(GABA) transporter, which removes GABA from the synaptic cleft. The SLC6A1 gene contains 15 exons and is approximately 25 kb by Lam et al. And it is mapped on 3p25.3. Zomot et al.(2007) showed that introduction of a negatively charged amino acid at or near 1 of the 2 putative sodium binding sites of the GABA transporter GAT1 from rat brain(also calledSLC6A1) renders both net flux and exchange of GABA largely chloride independent. By in vitro functional expression studies, the SLC6A1 insertion promoter(2 copies of the sequence) had significantly greater promoter activity than the noninsertion(1 copy of the sequence) promoter, which in turn had greater activity than a promoterless control. Studies of postmortem hippocampus from 69 African American individuals showed that the SLC6A1promoter genotype predicted SLC6A1 RNA expression and that overall SLC6A1 expression decreased with age.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human GABA Transporter 1(473-487aa WFYGVNRFYDNIQEM), identical to the related rat and mouse sequences.